Functional and Biological Assessment of an Implant Material for Treating Focal Cartilage Defects
A collaboration between Cardiff University, Industry & NHS Wales
Alpha Chondro Shield® is produced by Swiss Biomed Ortho and distributed by Hospital Innovations in the UK
The cell-free cartilage implant Alpha Chondro Shield® (ACS) is a cell-free cartilage replacement material designed to treat large focal cartilage defects of the knee. ACS relies on the migration and differentiation potential of mesenchymal stem cells (MSCs), which are released from the subchondral bone after the microfracture procedure. These attach to the fibres of the fleece material and form a blood clot, and eventually replace lost hyaline cartilage. This is advantageous over microfracture alone, particularly for larger defects where microfracture has shown increased chances of failure. Mechanical properties and the PGA in the implant material improves biocompatibility properties over other synthetics.
This project will investigate biological and functional properties of a surgical material called AlphaChondroShield®, and conventional surgical procedure microfracture both in vitro and in humans.
ACS® is an absorbable, cell-free cartilage resurfacing material made from a woven polyglycolic acid fleece.
Prof Cathy Holt
T:+44 (029) 20874533
PhD Student: Mr Nidal Khatib
Cathy is a Professor of Biomechanics and Orthopaedic Engineering and leads the Biomedical Engineering Research Group in the School of Engineering at Cardiff University.
Mr Phil Davies
Arthritis UK Biomechanics and Bioengineering Centre, Cardiff University
Dr Debbie Mason
School of Biosciences
Mr Chris Wilson
Cardiff and Vale Orthopaedic Centre
Cardiff and Vale UHB